منابع مشابه
Absence of BRAF gene mutations differentiates spitz nevi from malignant melanoma.
BACKGROUND Distinction of Spitz nevus from malignant melanoma is sometimes difficult on the basis of conventional histology. A high rate of BRAF gene mutations in malignant melanomas (66%) and nevi (82%) has recently been reported. MATERIALS AND METHODS We screened a series of 20 Spitz nevi for BRAF mutations in exons 11 and 15 by denaturing gradient gel electrophoresis (DGGE). RESULTS BRAF...
متن کاملOsteopontin expression in Spitz nevi.
1. de Waard-van der Spek FB, Mulder PG, Oranje AP. Prilocaine/lidocaine patch as a local premedication for skin biopsy in children. J Am Acad Dermatol. 1997; 37(3, pt 1):418-421. 2. Buckley MM, Benfield P. Eutectic lidocaine/prilocaine cream: a review of the topical anaesthetic/analgesic efficacy of a eutectic mixture of local anaesthetics (EMLA). Drugs. 1993;46(1):126-151. 3. Hoss DM, Gross EG...
متن کاملLack of BRAF mutations in uveal melanoma.
RAF proteins are serine/threonine kinases that mediate cellular responses to growth signals by activating the mitogen-activated protein kinase pathway. Mutations in the BRAF gene causing a V599E amino acid substitution that enhance the kinase activity have been described in >60% of cutaneous melanomas and premalignant melanocytic lesions. We have investigated the frequency of BRAF mutations at ...
متن کاملThe Spectrum of Spitz Nevi
Main Outcome Measure: Frequency of dermoscopic patterns within the different histopathologic subtypes of Spitz nevi. Results: Overlapping clinical, dermoscopic, and histopathologic findings were observed among PSN, RN, and PSRN, thereby justifying their inclusion into the single PSRN diagnostic category. Asymmetry was the most frequent indicator of histopathologic ASN (79%; n=11); in only 4 cas...
متن کاملPolyclonality of BRAF mutations in acquired melanocytic nevi.
Melanocytic nevi are thought to be senescent clones of melanocytes that have acquired an oncogenic BRAF mutation. BRAF mutation is considered to be a crucial step in the initiation of melanocyte transformation. However, using immunomagnetic separation or laser-capture microdissection, we examined BRAF mutations in sets of approximately 50 single cells isolated from acquired melanocytic nevi fro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2004
ISSN: 0022-202X
DOI: 10.1111/j.0022-202x.2004.22530.x